What is SOD
SOD is a kind of enzyme that can catalyze the disproportionation of superoxide anion radical (O2 -) to H2O2 and O2. This enzyme is widely distributed and has been isolated from bacteria, fungi, algae, plants, protozoa, insects, fish and mammals.
The superoxide dismutase is very stable. The SOD of bovine red blood cells is still rarely inactivated after being heated at 75 ℃ for several minutes. It is also relatively stable to acids and bases, and can react within the range of pH 5.3~10.5.
Superoxide dismutase has the functions of antioxidation and anti-aging, and its mechanism is mainly to eliminate superoxide anion free radicals (O2 -) which are harmful to the body. Superoxide dismutase (SOD) has a unique effect on the treatment of diseases caused by superoxide free radicals (O2 -), such as oxygen poisoning, acute inflammation, various autoimmune diseases, radiation sickness and senile cataract. It is a new promising pharmaceutical enzyme. Superoxide dismutase is being studied as an anti-aging drug.
Basic Function
The main function of SOD is to catalyze the disproportionation of superoxide anion radicals into hydrogen peroxide and oxygen, and the superoxide anion radicals produced are normal metabolites in the organism. However, the accumulation of free radicals will lead to lipid peroxidation of cell membrane, which will cause membrane fission, leading to cell damage and even death. SOD is the most important and best free radical scavenger in the organism to maintain the metabolic balance of the organism.
In addition, SOD has significant effect on the treatment of myocardial infarction, vascular heart disease, collagen disease, neonatal dyspnea syndrome, edema, emphysema, oxygen poisoning and other diseases, as well as psoriasis, dermatitis, eczema, pruritus and other skin diseases. As a superoxide anion radical scavenger, SOD is widely used in delaying human aging, preventing diseases, improving human immunity, and as an additive in food and cosmetics. Since SOD was discovered as the first enzyme with superoxide anion as its substrate, it has fully proved its effective role in preventing and treating diseases related to superoxide free radicals. When the body produces too much superoxide anion or the concentration of SOD is too low, excessive superoxide anion will cause disease, and exogenous SOD can effectively prevent and cure it.
Application range of SOD
1. Medicine
The superoxide free radicals in the body can cause various diseases. As its natural scavenger, SOD keeps a dynamic balance with it under normal conditions. However, under pathological conditions, excessive superoxide free radicals are produced, and the SOD produced by the body itself cannot completely eliminate these excessive superoxide free radicals, which are harmful to the body. SOD can catalyze its disproportionation reaction and alleviate the disease.
Workers engaged in radiation work with poor protection will form various products in their bodies after receiving ionizing radiation, and the products will have a chain reaction, generating many free radicals to attack the human body, leading to radiation sickness. The increase of SOD can inhibit the formation of tumor caused by radiation, increase the differentiation ability of fibroblast, and effectively prevent the malignant development of tumor.
In addition, SOD can be used not only for disease treatment, but also for clinical examination. For example, SOD can be used as a diagnostic indicator of silicosis.
2. Food industry
It has been proved that adding SOD into food as a natural antioxidant can be used as a preservative. Clinical trials have shown that SOD oral administration is effective and can be absorbed into the human body through the gastrointestinal tract. Therefore, SOD chewing gum, SOD buccal tablets and oral liquid have emerged successively and become one of the important ways to supplement SOD in vitro.
3. Daily chemical industry
The application of SOD in the daily chemical industry is mainly skin care products and toothpaste.
SOD has the following functions in skin care products: First, as a cosmetic additive, it can prevent skin aging, reduce wrinkles and freckles, and play a role in skin care, such as Dabao SOD honey; The second is to prevent and treat skin diseases, such as dermatitis, acne, skin burns, etc.
Because SOD has anti-inflammatory effect, is pure natural, non-toxic side effects, so it plays an important role in oral and dental health care, such as toothpaste, mouthwash, chewing gum, etc. can be used to prevent and treat periodontitis.
4.Agriculture
Overexpression of SOD in transgenic plants can improve the resistance of plants to harsh environments to varying degrees, and overexpression of Mn SOD gene can improve the tolerance of transgenic plants to oxygen stress to a certain extent. By means of genetic engineering, increasing the expression of SOD in plants can greatly enhance the stress resistance of plants. For example, over expression of Fe-SOD can enhance the resistance of chloroplast plasma membrane and photosynthetic system II to MV (methyl viologen) and high salt peroxidation stress.
The king of "healthy SOD" vitality
Rosa roxburghii SOD is extracted from fresh Rosa roxburghii fruit. The fresh fruit of Rosa roxburghii contains 541.1~4500 active units per gram, and no higher fruit has been found at present. It is the source of high SOD content of medical enzymes.
