What is Ginkgo Biloba Extract Powder?
Ginkgo Biloba Extract Powder is the dry leaf extract of the Ginkgo biloba plant, which is light yellow-brown flowable powder, bitter in taste, and has the effects of promoting blood circulation, removing blood stasis, and dredging collaterals. Widely used in medicine, health products, food additives, functional beverages, cosmetics, and other fields.
Ginkgo biloba is still used in Chinese medicine to treat memory loss, stomach pain, dysentery, high blood pressure, mental stress, and respiratory problems such as asthma, bronchitis, and poor circulation and the anxiety it causes. The active ingredients of Ginkgo biloba are the terpene moieties, which include ginkgolides and bilobalides. These ginkgo flavonoid-glucoside components have powerful antioxidant and free radical scavenging capabilities. Ginkgo biloba extract not only can significantly antagonize PAF receptors but also can play a role in anti-inflammation, and anti-allergy, dilating blood vessels, protecting cardiovascular and cerebrovascular, improving peripheral blood circulation, lowering serum cholesterol, and assisting anti-cancer. It is widely used in the prevention and health care of cardiovascular, cerebrovascular, nervous, and other system diseases.
Ginkgo biloba extract can improve the blood circulation of various parts of the human body, including the blood circulation of the brain. Therefore, it can effectively treat and prevent a wide range of dysfunctional diseases, including heart, brain, and vascular diseases, brain damage, asthma, Sexual function, allergic diseases, even Alzheimer's disease and senile dementia, vision and hearing, and other sensory diseases.
Ginkgolide B contained in Ginkgo biloba has the following pharmacological effects and clinical application prospects: ① It can reduce and treat various inflammatory reactions; ② It has a certain curative effect on arrhythmia caused by ischemia, and can antagonize The extravasation of tissue blood vessels caused by PAF; ③ long-term use, can improve cerebral circulation, delay aging and treat senile mental retardation; ④ has a certain protective effect on gastrointestinal ulcers; ⑤ can improve some liver dysfunction; ⑥It can be used to treat the immune damage of the kidney; ⑦It has certain effects on certain endocrine functions such as hypothalamic neuropeptides; ⑧It has a certain effect on the reproductive system; ⑨It has a certain regulatory effect on the function of the immune system; Diseases of the ears and eyes caused by PAF. Judging from the current research progress, ginkgolide B has preventive and therapeutic effects on septic shock, endotoxemia, systemic inflammatory response syndrome, myocardial ischemic damage, cerebral ischemic damage, and senile mental retardation. Alleviating and healing effects.
Quality Control COA
ITEM | STANDARD | TEST RESULT | TEST METHOD |
Total Flavone | ≥24.0% | 26.12% | HPLC |
Physical & Chemical | |||
Appearance | Light Yellow to Brown fine powder | Complies | Visual |
Odor | Taste bitter | Complies | Organoleptic |
Bulk Desity | 55g/100ml-68g/100ml | Complies | Organoleptic |
Loss on Drying | ≤5.0% | 2.92% | USP<731> |
Ash | ≤0.8% | 0.41% | USP<281> |
Heavy Metal | |||
Total Heavy Metal | ≤10.0ppm | ≤6.00ppm | ICP-MS |
Pb | ≤1.0ppm | 0.365ppm | ICP-MS |
As | ≤1.0ppm | 0.235ppm | ICP-MS |
Cd | ≤1.0ppm | 0.231ppm | ICP-MS |
Hg | ≤0.1ppm | 0.012ppm | ICP-MS |
Microbiological Test | |||
Total Plate Count | ≤1,000cfu/g | <300cfu/g | AOAC |
Yeast & Mold | ≤50cfu/g | <20cfu/g | AOAC |
E.Coli | Negative | Complies | AOAC |
Staphylococcus | Negative | Complies | AOAC |
P.Aeruginosa | Negative | Complies | AOAC |
Salmonella | Negative | Complies | AOAC |
Function
1. Ginkgo biloba and hyperlipidemia
Ginkgo Extract contains chemical components such as flavonoids, lactones, and long-chain phenols. The active ingredients of its preparations or extracts can correct hyperlipidemia microcirculation disorders, and can significantly reduce serum cholesterol and improve blood viscosity. The test results showed that the contents of total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) in the serum of rats in the middle and high dose groups were all significantly reduced, and the contents of high-density lipoprotein cholesterol (HDL-C) were significantly reduced. -C) The content is significantly increased, indicating that Ginkgo biloba can reduce blood lipids in hyperlipidemia rats, indicating that it can improve lipoprotein metabolism and "blood thickness" caused by excessive cholesterol intake, and has a role in preventing hyperlipidemia Obvious effect.
2. Ginkgo biloba and atherosclerosis
Ginkgo biloba extract can greatly reduce the formation of neointima in the treatment of atherosclerosis in type 2 diabetic rats, and the EGb200 and EGb10 groups are accompanied by increased proliferation and apoptosis of vascular smooth muscle cells. Improve the state of atherosclerosis. Antioxidative effect of Ginkgo biloba extract on atherosclerosis in type 2 diabetic rats Drugs and Clinics 2019.09.051. 1672-4062.
3. Ginkgo biloba and high blood pressure
Ginkgo biloba extract can simultaneously reduce the adverse effects of blood cholesterol, triacylglycerol, and very low-density lipoprotein on the human body, reduce blood lipids, improve microcirculation, and inhibit blood coagulation, thereby promoting a significant therapeutic effect on hypertension.
4. Ginkgo and diabetes
Ginkgo biloba extract (GBE) is an active substance extracted from Ginkgo biloba by scientists in the academic research community. The main active ingredients are ginkgo flavonoids and ginkgolides. By establishing a model of diabetic cardiomyopathy in rats and injecting a certain dose of GBE intraperitoneally, it was found that after the intervention of GBE, the blood sugar index of diabetic rats could be significantly reduced, and the blood insulin level was significantly increased. By establishing a type 2 diabetes rat model and giving different doses of GBE orally, it was found that GBE can lower blood sugar and improve insulin resistance.
5. Ginkgo biloba and cerebral vasospasm
The characteristic of Ginkgo biloba extract’s effect on blood vessels is that it can eliminate vasospasm, restore normal circulatory function in the paralyzed area, maintain the tension difference between arteries, and facilitate the timely removal of metabolites in the vein. Ginkgolides were able to reduce vasospasm induced by thromboxane analogues by 90% within fifteen minutes.
Application
Ginkgo Biloba Extract can be used in medicine.
The medicinal value and application of Ginkgo biloba extract are extremely extensive. Using advanced technology, technology and equipment, through further extraction, separation, and purification, its pharmacological effects are more obvious. In addition to the significant antagonism of PAF receptors, it can also be anti-inflammatory, anti-allergic, dilating blood vessels, protecting cardiovascular and cerebrovascular, Improving peripheral blood circulation, lowering serum cholesterol, and assisting anti-cancer effects, can be widely used in the prevention and health care of cardiovascular, cerebrovascular, nervous and other system diseases.
It is understood that CFDA has approved dozens of dosage forms of Ginkgo biloba extract, and those produced by domestic manufacturers include Ginkgo biloba leaves, capsules, granules, soft capsules, dispersible tablets, pills, tinctures, drops, oral liquids, Ginkgo biloba extract injections, etc. .
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