Phellodendron Amurense Bark Extract

What is Phellodendron Amurense Bark Extract?

Phellodendri is one of the most commonly used heat-clearing medicines in traditional Chinese medicine. There are many types of heat-clearing medicines, which belong to bitter-cold clearing-heat medicines. Bitter-cold can not only clear away heat but also dry dampness. Therefore, the most commonly used combination of Phellodendron species is with Zhimu such as Dabuyin Pill and Zhibai Dihuang Pill. Juvenile wet dreams. In addition, it can also be used together with Atractylodes, namely Ermiao Wan, Atractylodes and Treats have the effect of removing bitter cold, clearing heat and drying dampness, scorching damp heat, soreness of waist and legs, athlete's foot, sweating, genital sweating, hydrangea wind That is, scrotal dermatitis, female genital dampness or vulvar itching, and male scrotum dampness can all be treated with Ermiao Pills. Therefore, Cortex Phellodendri can not only clear away heat and dry dampness, but also nourish yin and clear heat, and clear away fire.

Amurense Bark Extract has a broad-spectrum antibacterial effect and has a particularly strong inhibitory effect on various types of Shigella. In Huanglian Jiedu Decoction, the antibacterial activity of Coptis chinensis and Cortex Phellodendri has a synergistic effect. This product has strong inhibitory and killing effects on Mycobacterium tuberculosis and Leptospira. This product has a significant inhibitory effect on a variety of fungi and Trichomonas. This product has the effect of anti-influenza virus and has an obvious selective inhibitory effect on hepatitis B surface antigen. Its mechanism is related to its strong inhibition of bacterial respiration and RNA synthesis, and can also significantly reduce the production of Staphylococcus aureus toxin and promote the phagocytosis of bacteria by leukocytes. It has a significant antihypertensive effect. It contains a variety of alkaloids such as berberine, Phellodendron, palmatine, jatrorrhizine, and magnolia alkaloids that have antihypertensive effects. Its antihypertensive mechanism is related to blocking ganglion, inhibiting vascular center, and resisting sympathetic nerve mediators.

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Function

1. Immunosuppression.

Phellodendron phellodendri has the effect of inhibiting cellular immune response, and its active substances are phellodendron alkaloid and magnolidine, both of which can inhibit the host response (GvH) of local transplanted tissue in mice. Also inhibited the induction phase, but not the response phase, of picrylchloride-induced delayed-type hypersensitivity (DTH) mice. Further studies have shown that phellodendri can inhibit the local semi-homologous GvH response and the systemic allogeneic GvH response in mice. It can also inhibit the induction of DTH in mice induced by sheep blood red blood cells (SRBC) and the induction of DTH in guinea pigs induced by the tuberculosis vaccine. period, but it did not affect the production of antibodies against SRBC in mice. Another literature reported that Phellodendron decoction significantly inhibited DTH induced by dinitrofluorobenzene (DNFD) in mice. The production and secretion of cytokines such as factor alpha (TNF-α) and interleukin 2 (IL-2), thereby inhibiting the immune response and reducing inflammatory damage.

2. Anti-tumor effect

Phellodendron Amurense Extract has a photosensitivity inhibitory effect on BGC823 human gastric cancer cells. It has no photosensitive adhesion-induced aberration effect on chromosomes but can delay the cell cycle process in the S phase. Electron microscope observation showed that Cortex Phellodendri caused extensive swelling and expansion of mitochondria and endoplasmic reticulum in the experimental group, and ribosomes decreased significantly. The key target of its photosensitization is the biofilm.

3. Anti-ulcer effect

The production of a large number of reactive oxygen species in the gastric mucosa is one of the reasons for the occurrence of bundled water immersion stress ulcers, and the Phellodendron phellodendri component from which the berberine has been removed has an inhibitory effect on the bundled water immersion stress gastric ulcers in mice. The study of its mechanism found that the component had no effect on the SOD activity of the normal mice endogenous gastric mucosa, but it had a significant inhibitory effect on the reduction of the SOD activity of the gastric mucosa in mice under the stress load of water immersion and binding, and also Significantly inhibited the reduction of the amount of PGE2 in the gastric mucosa of rats induced by indomethacin. The amount of PGE2 in the gastric mucosa before water immersion was significantly increased in mice subjected to water bundling stress, and the decreasing trend of PGE2 amount after water immersion was suppressed. No effect was found on gastric mucosal blood flow.

4. Antibacterial effect

Phellodendron chinensis water extracts also showed drug resistance to multidrug-resistant clinically isolated Escherichia coli (UPEC) strains 132 and 136. However, hemagglutination experiments showed that it has an inhibitory effect on the adhesion properties of the bacteria, which may be used as the mechanism of Phellodendron chinensis for the treatment of urinary tract infections. The inhibitory effect on Helicobacter pylori is no less than that of ampicillin. It also has an inhibitory effect on the activity of Propionibacterium acnes lipase and also shows activity against several anaerobic bacteria such as Bacillus fragilis, Bacillus melanogenum, Bacteroides polytype, and Peptostreptococcus.

Phellodendron bark has a broad-spectrum antibacterial effect and has a very good inhibitory effect on Shigella. Phellodendron bark can resist influenza virus, and can also help reduce the damage and impact of aureus on white blood cells. If bacterial infection occurs frequently, then you can drink more cork bark water, which can also play a role in preventing bacterial infection.

5. Antihypertensive effect

Phellodendron Bark Extract has the effect of lowering blood pressure, and the effect will be more obvious. In fact, you can know that there are many kinds of alkaloids and some magnolia alkaloids. These ingredients have obvious antihypertensive effect, mainly by blocking the ganglion. , by inhibiting the vascular center and sympathetic nerve to achieve the effect. In addition, you can also try drinking ambergris antihypertensive tea to regulate blood pressure. This is a blue-cap-certified healthcare tea drink. It is composed of Chinese herbal ingredients such as cassia seeds, stevia, and dandelion. It can be effectively soaked in water. It has the effect of assisting in lowering blood pressure. If you insist on drinking water for a month, you can obviously find that the problem of high blood pressure has been significantly improved (click to view user feedback).

6. The effect on the digestive system

Phellodendron bark also has some important effects on the digestive system, it can help to play a significant protective role, it can reduce the contraction of the intestinal tract, and it can also stimulate the smooth muscle. Phellodendron bark can help to promote the activity of trypsin, of course, the effect of this aspect is not very prominent.

7. Antitussive effect

Phellodendron bark can help play a choleretic effect, can promote the secretion of bile and pancreatic juice, and also has a very good politician effect, because it contains geraniene, which is a substance obtained from a volatile oil, which can better Relieve cough symptoms.

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